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Identifying potentially O-GlcNAcylated proteins using metabolic labeling, bioorthogonal enrichment, and Western blotting

O-GlcNAcylation is a widespread posttranslational modification of intracellular proteins. Phenotypic and genetic experiments have established key roles for O-GlcNAc in development, mammalian cell survival, and several human diseases. However, the underlying mechanisms by which this modification alte...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Darabedian, Narek, Pratt, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6860911/
https://ncbi.nlm.nih.gov/pubmed/31155058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.02.017
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