A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology

Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they acquire different patterns of transcriptional activation, cytokine expression and cellular metabolism which collectively constitute a contin...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Zhao, Chen, Mirando, Adam C., Sové, Richard J., Medeiros, Thalyta X., Annex, Brian H., Popel, Aleksander S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6860420/
https://ncbi.nlm.nih.gov/pubmed/31738746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007468
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