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Targeting Topoisomerase I in the Era of Precision Medicine
Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years. Due to their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage complexes (TOP1CCs), camptothecins are also widely used to elucidate the DNA repair pathways associated with DNA-protein cro...
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| Publicado no: | Clin Cancer Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858945/ https://ncbi.nlm.nih.gov/pubmed/31227499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1089 |
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