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Engineering orthogonal signaling pathways reveals the sparse occupancy of sequence space
Gene duplication is a common and powerful mechanism by which cells create new signaling pathways(1,2), but recently duplicated proteins typically must become insulated from each other, and from other paralogs, to prevent unwanted cross-talk(3). A similar challenge arises when new sensors or syntheti...
Uloženo v:
| Vydáno v: | Nature |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858568/ https://ncbi.nlm.nih.gov/pubmed/31645757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1639-8 |
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