Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)

INTRODUCTION: Observational studies have demonstrated an association between vitamin D deficiency and increased risk of morbidity and mortality in critically ill patients. Cohort studies and pilot trials have suggested promising beneficial effects of vitamin D replacement in the critical ill, at lea...

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Vydáno v:BMJ Open
Hlavní autoři: Amrein, Karin, Parekh, Dhruv, Westphal, Sabine, Preiser, Jean-Charles, Berghold, Andrea, Riedl, Regina, Eller, Philipp, Schellongowski, Peter, Thickett, David, Meybohm, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2019
Témata:
Intensive Care
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858186/
https://ncbi.nlm.nih.gov/pubmed/31722941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2019-031083
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