Binding Immunoglobulin Protein (BIP) Inhibits TNF‐α–Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model

OBJECTIVE: The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis and is recapitulated in the human tumor necrosis factor transgenic (hTNFtg) mouse model. We investigated whether extracellular binding immunoglobulin protein (BiP) would protect the h...

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Vydáno v:ACR Open Rheumatol
Hlavní autoři: Zaiss, Mario M., Hall, Christopher, McGowan, Neil W. A., Babb, Rebecca, Devlia, Vikesh, Lucas, Sébastien, Meghji, Sajeda, Henderson, Brian, Bozec, Aline, Schett, Georg, David, Jean‐Pierre, Panayi, Gabriel S., Grigoriadis, Agamemnon E., Corrigall, Valerie M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857990/
https://ncbi.nlm.nih.gov/pubmed/31777818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acr2.11060
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