Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1

UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity. For example, adverse drug reactions when patients receive CPT-11 (iri...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Takaoka, Yutaka, Takeuchi, Atsuko, Sugano, Aki, Miura, Kenji, Ohta, Mika, Suzuki, Takashi, Kobayashi, Daisuke, Kimura, Takuji, Sato, Juichi, Ban, Nobutaro, Nishio, Hisahide, Sakaeda, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857941/
https://ncbi.nlm.nih.gov/pubmed/31730632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225244
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