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Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans

MicroRNAs target complementary mRNAs for degradation or translational repression, reducing or preventing protein synthesis. In Caenorhabditis elegans, the transcription factor HBL-1 (Hunchback-like 1) promotes early larval (L2)-stage cell fates, and the let-7 family microRNAs temporally downregulate...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Development
Päätekijät: Ilbay, Orkan, Ambros, Victor
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857590/
https://ncbi.nlm.nih.gov/pubmed/31597658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.183111
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