LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer

Specificity of RNAi to selected target is challenged by off-target effects, both canonical and non-canonical. Notably, more than half of all human microRNAs are co-expressed with hosting them proteincoding genes. Here we dissect regulatory subnetwork centered on IGFBP6 gene, which is associated with...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Shkurnikov, Maxim, Nikulin, Sergey, Nersisyan, Stepan, Poloznikov, Andrey, Zaidi, Shan, Baranova, Ancha, Schumacher, Udo, Wicklein, Daniel, Tonevitsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857517/
https://ncbi.nlm.nih.gov/pubmed/31781574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00122
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