Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. According to the amyloid hypothesis, the accumulation and deposition of amyloid-beta (Aβ) peptides play a key role in AD. Soluble Aβ (sAβ) oligomers were shown to be involved in pathological hypersynchronisation of brain re...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Ben-Nejma, Inès R. H., Keliris, Aneta J., Daans, Jasmijn, Ponsaerts, Peter, Verhoye, Marleen, Van der Linden, Annemie, Keliris, Georgios A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857138/
https://ncbi.nlm.nih.gov/pubmed/31727182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0810-7
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