Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion

Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) is acknowledged as a distinct leukemia entity in the 2016 updated World Health Organization (WHO) classification. NPM1-mutated AML patients are correlated with higher extramedullary involvement. Epithelial-mesenchymal transition (EMT) is...

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Veröffentlicht in:J Cancer
Hauptverfasser: Yang, Liyuan, Wang, Lu, Yang, Zailin, Jin, Hongjun, Zou, Qin, Zhan, Qian, Tang, Yuting, Tao, Yao, Lei, Li, Jing, Yipei, Jiang, Xueke, Zhang, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856892/
https://ncbi.nlm.nih.gov/pubmed/31777586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.30223
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