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The DOT1L inhibitor Pinometostat decreases the host-response against infections: Considerations about its use in human therapy
Patients with acute myeloid leukemia frequently present translocations of MLL gene. Rearrangements of MLL protein (MLL-r) in complexes that contain the histone methyltransferase DOT1L are common, which elicit abnormal methylation of lysine 79 of histone H3 at MLL target genes. Phase 1 clinical studi...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6856118/ https://ncbi.nlm.nih.gov/pubmed/31727944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53239-6 |
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