Structural topology defines protective CD8(+) T cell epitopes in the HIV proteome

Mutationally constrained epitopes of variable pathogens represent promising targets for vaccine design but are not reliably identified by sequence conservation. In this study, we employed structure-based network analysis, which applies network theory to HIV protein structure data to quantitate the t...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Gaiha, Gaurav D., Rossin, Elizabeth J., Urbach, Jonathan, Landeros, Christian, Collins, David R., Nwonu, Chioma, Muzhingi, Itai, Anahtar, Melis N., Waring, Olivia M., Piechocka-Trocha, Alicja, Waring, Michael, Worrall, Daniel P., Ghebremichael, Musie S., Newman, Ruchi M., Power, Karen A., Allen, Todd M., Chodosh, James, Walker, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855781/
https://ncbi.nlm.nih.gov/pubmed/31048489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav5095
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