CYP2C19 and STAT6 Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis

OBJECTIVE: Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic esophagitis (EoE); however, only 30% to 60% of patients respond. Common genetic variants in CYP2C19 and STAT6 associate with PPI plasma concentration and magnitude of inflammatory response, respectively. Our objecti...

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Pubblicato in:J Pediatr Gastroenterol Nutr
Autori principali: Mougey, Edward B., Williams, Andre, Coyne, Ashlan J. Kunz, Gutiérrez-Junquera, Carolina, Fernández-Fernández, Sonia, Cilleruelo, Maria Luz, Rayo, Ana, Echeverría, Luis, Román, Enriqueta, González Lois, Carmen, Chao, Montserrat, Al-Atrash, Hadeel, Lima, John J., Franciosi, James P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2019
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Original Article: Gastroenterology: Eosinophilic GI Disorders
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855320/
https://ncbi.nlm.nih.gov/pubmed/31490856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPG.0000000000002480
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