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Transcriptional Mutagenesis Prevents Ribosomal DNA Deterioration: The Role of Duplications and Deletions

Clashes between transcription and replication complexes can cause point mutations and chromosome rearrangements on heavily transcribed genes. In eukaryotic ribosomal RNA genes, the system that prevents transcription–replication conflicts also causes frequent copy number variation. Such fast mutation...

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Detalles Bibliográficos
Publicado en:Genome Biol Evol
Main Authors: Colizzi, Enrico Sandro, Hogeweg, Paulien
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855279/
https://ncbi.nlm.nih.gov/pubmed/31651950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evz235
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