Probing the Druggablility on the Interface of the Protein–Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer

Modulating protein–protein interactions (PPIs) with small drug-like molecules targeting it exhibits great promise in modern drug discovery. G protein-coupled receptors (GPCRs) are the largest family of targeted proteins and could form dimers in living biological cells through PPIs. However, compared...

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Vydáno v:Front Pharmacol
Hlavní autoři: Shen, Liting, Yuan, Yuan, Guo, Yanzhi, Li, Menglong, Li, Chuan, Pu, Xuemei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855241/
https://ncbi.nlm.nih.gov/pubmed/31787895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01310
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