The importance of p53 pathway genetics in inherited and somatic cancer genomes

Decades of research has proven that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that...

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Detalhes bibliográficos
Publicado no:Nat Rev Cancer
Main Authors: Stracquadanio, Giovanni, Wang, Xuting, Wallace, Marsha, Grawenda, Anna M., Zhang, Ping, Hewitt, Juliet, Zeron-Medina, Jorge, Castro-Giner, Francesc, Tomlinson, Ian P., Goding, Colin R., Cygan, Kamil J., Fairbrother, William G., Thomas, Laurent F., Sætrom, Pål, Gemignani, Frederica, Landi, Stefano, Schuster-Boeckler, Benjamin, Bell, Douglas A., Bond, Gareth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854702/
https://ncbi.nlm.nih.gov/pubmed/27009395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2016.15
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