Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model

Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is unclear whether succinate accumulation contributes to the onset of epilepsy or seizures. We sought to investigate changes in succinate, oxidativ...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Zhang, Yurong, Zhang, Mengdi, Zhu, Wei, Yu, Jie, Wang, Qiaoyun, Zhang, Jinjin, Cui, Yaru, Pan, Xiaohong, Gao, Xue, Sun, Hongliu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854095/
https://ncbi.nlm.nih.gov/pubmed/31707354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101365
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