Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

Dysregulation of retinoblastoma (Rb) signaling pathway have been established as a requirement for glioblastoma (GBM) initiation and progression, which suggests that blockade of CDK4/6-Rb signaling axis for GBM treatment. Palbociclib, a selective inhibitor of the cyclin-dependent kinases CDK4/6, has...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Songlin, Yuan, Dun, Li, Yifeng, Qi, Qi, Guo, Bingzhong, Yang, Shun, Zhou, Jilin, Xu, Lu, Chen, Tiange, Yang, Chenxing, Liu, Junyu, Li, Buyan, Yao, Li, Jiang, Weixi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854038/
https://ncbi.nlm.nih.gov/pubmed/31787897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01316
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