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Cell-level somatic mutation detection from single-cell RNA sequencing

MOTIVATION: Both single-cell RNA sequencing (scRNA-seq) and DNA sequencing (scDNA-seq) have been applied for cell-level genomic profiling. For mutation profiling, the latter seems more natural. However, the task is highly challenging due to the limited input materials from only two copies of DNA mol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioinformatics
Hauptverfasser: Vu, Trung Nghia, Nguyen, Ha-Nam, Calza, Stefano, Kalari, Krishna R, Wang, Liewei, Pawitan, Yudi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853710/
https://ncbi.nlm.nih.gov/pubmed/31028395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz288
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