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Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
BACKGROUND: We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC). METHODS: Changes in glycolysis-related molecules and glycolytic activity were evaluated in PD-L1(low) and PD-L1(high) NSCLC cells after transfection or knockdown of PD-L1, respectively...
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出版年: | J Exp Clin Cancer Res |
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主要な著者: | , , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2019
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6852926/ https://ncbi.nlm.nih.gov/pubmed/31718692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1407-5 |
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