Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

BACKGROUND: We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC). METHODS: Changes in glycolysis-related molecules and glycolytic activity were evaluated in PD-L1(low) and PD-L1(high) NSCLC cells after transfection or knockdown of PD-L1, respectively...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Kim, Sehui, Jang, Ji-Young, Koh, Jaemoon, Kwon, Dohee, Kim, Young A., Paeng, Jin Chul, Ock, Chan-Young, Keam, Bhumsuk, Kim, Miso, Kim, Tae Min, Heo, Dae Seog, Chung, Doo Hyun, Jeon, Yoon Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852926/
https://ncbi.nlm.nih.gov/pubmed/31718692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1407-5
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