Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer

BACKGROUND: Several reports indicated that the expression of Yes-associated protein (YAP) was associated with multi-drug resistance. Acidic microenvironment increased by the overexpression of vacuolar-ATPase (V-ATPase) was also observed in tumor growth and drug resistance. We hypothesize that proton...

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Udgivet i:BMC Mol Cell Biol
Main Authors: He, Jing, Shi, Xiao-Yan, Li, Zhi-min, Pan, Xiao-hua, Li, Ze-Lian, Chen, Ying, Yan, Shi-Jie, Xiao, Lan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852784/
https://ncbi.nlm.nih.gov/pubmed/31718559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-019-0227-y
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