Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti‐fibrosis activity

Fibrosis is characterized by the progressive alteration of the tissue structure due to the excessive production of extracellular matrix (ECM). The signaling system encompassing Receptor Activator of Nuclear factor NF‐κB Ligand (RANKL)/RANK/Osteoprotegerin (OPG) was discovered to play an important ro...

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Bibliografiske detaljer
Udgivet i:FEBS J
Main Authors: Wang, Yizhou, Michiels, Timo, Setroikromo, Rita, van Merkerk, Ronald, Cool, Robbert H., Quax, Wim J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852375/
https://ncbi.nlm.nih.gov/pubmed/31081236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14925
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