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Pharmacokinetic/Pharmacodynamic Modeling to Support the Re‐approval of Gemtuzumab Ozogamicin

Gemtuzumab ozogamicin (Mylotarg; Pfizer, New York, NY) was the first antibody–drug conjugate to be approved for CD33‐positive acute myeloid leukemia (AML). However, it was voluntarily withdrawn from the US market due to lack of clinical benefit in the confirmatory phase III trial. In 2012, several i...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Fostvedt, Luke K., Hibma, Jennifer E., Masters, Joanna C., Vandendries, Erik, Ruiz‐Garcia, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6852000/
https://ncbi.nlm.nih.gov/pubmed/31070776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1500
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