A novel specific peroxisome proliferator‐activated receptor γ (PPARγ) modulator YR4‐42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet‐induced obese mice

AIMS: To evaluate a novel tetrahydroisoquinoline derivative YR4‐42 as a selective peroxisome proliferator‐activated receptor γ (PPARγ) modulator (SPPARM) and explore its anti‐diabetic effects in vitro and in vivo. MATERIALS AND METHODS: Using two standard full PPARγ agonists rosiglitazone and piogli...

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Veröffentlicht in:Diabetes Obes Metab
Hauptverfasser: Huan, Yi, Pan, Xuan, Peng, Jun, Jia, Chunming, Sun, Sujuan, Bai, Guoliang, Wang, Xing, Zhou, Tian, Li, Rongcui, Liu, Shuainan, Li, Caina, Liu, Quan, Liu, Zhanzhu, Shen, Zhufang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851555/
https://ncbi.nlm.nih.gov/pubmed/31364797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13843
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