Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease

Chronic granulomatous disease (CGD) is a genetic disorder of the NADPH oxidase characterized by increased susceptibility to infections and hyperinflammation associated with defective autophagy and increased inflammasome activation. Herein, we demonstrate that thymosin β4 (Tβ4), a g-actin sequesterin...

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Pubblicato in:Life Sci Alliance
Autori principali: Renga, Giorgia, Oikonomou, Vasilis, Moretti, Silvia, Stincardini, Claudia, Bellet, Marina M, Pariano, Marilena, Bartoli, Andrea, Brancorsini, Stefano, Mosci, Paolo, Finocchi, Andrea, Rossi, Paolo, Costantini, Claudio, Garaci, Enrico, Goldstein, Allan L, Romani, Luigina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Life Science Alliance LLC 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851533/
https://ncbi.nlm.nih.gov/pubmed/31719116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900432
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