Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease

Autosomal-dominant polycystic kidney disease (ADPKD) induces a secretory phenotype, resulting in multiple fluid-filled cysts. We have previously demonstrated that VX-809, a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), reduces cyst growth. Here, we show that in normal...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Yanda, Murali K., Cha, Boyoung, Cebotaru, Cristina V., Cebotaru, Liudmila
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851297/
https://ncbi.nlm.nih.gov/pubmed/31570523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010320
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