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STS-NLSP: A Network-Based Label Space Partition Method for Predicting the Specificity of Membrane Transporter Substrates Using a Hybrid Feature of Structural and Semantic Similarity

Membrane transport proteins play crucial roles in the pharmacokinetics of substrate drugs, the drug resistance in cancer and are vital to the process of drug discovery, development and anti-cancer therapeutics. However, experimental methods to profile a substrate drug against a panel of transporters...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Bioeng Biotechnol
Prif Awduron: Wang, Xiangeng, Zhu, Xiaolei, Ye, Mingzhi, Wang, Yanjing, Li, Cheng-Dong, Xiong, Yi, Wei, Dong-Qing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851049/
https://ncbi.nlm.nih.gov/pubmed/31781551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00306
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