Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells

Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1...

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Vydáno v:Front Endocrinol (Lausanne)
Hlavní autoři: Aljaibeji, Hayat, Mukhopadhyay, Debasmita, Mohammed, Abdul Khader, Dhaiban, Sarah, Hachim, Mahmood Y., Elemam, Noha M., Sulaiman, Nabil, Salehi, Albert, Taneera, Jalal
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Endocrinology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851018/
https://ncbi.nlm.nih.gov/pubmed/31781030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00735
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