Arginine‐ but not alanine‐rich carboxy‐termini trigger nuclear translocation of mutant keratin 10 in ichthyosis with confetti

Ichthyosis with confetti (IWC) is a genodermatosis associated with dominant‐negative variants in keratin 10 (KRT10) or keratin 1 (KRT1). These frameshift variants result in extended aberrant proteins, localized to the nucleus rather than the cytoplasm. This mislocalization is thought to occur as a r...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Renz, Patricia, Imahorn, Elias, Spoerri, Iris, Aushev, Magomet, March, Oliver P., Wariwoda, Hedwig, Von Arb, Sarah, Volz, Andreas, Itin, Peter H., Reichelt, Julia, Burger, Bettina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850952/
https://ncbi.nlm.nih.gov/pubmed/31638346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14727
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