Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

Cocaine is an addictive drug that acts in brain reward areas. Recent evidence suggests that cocaine stimulates synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in midbrain, increasing dopamine neuron activity via disinhibition. Although a mechanism for cocaine-stimulated 2-AG synthesis...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Nakamura, Yoki, Dryanovski, Dilyan I, Kimura, Yuriko, Jackson, Shelley N, Woods, Amina S, Yasui, Yuko, Tsai, Shang-Yi, Patel, Sachin, Covey, Daniel P, Su, Tsung-Ping, Lupica, Carl R
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850780/
https://ncbi.nlm.nih.gov/pubmed/31596232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47209
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