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Temperature‐dependent irreversible conformational change of recombinant ADAMTS13 upon metal ion chelation
BACKGROUND: The catalytic domain of ADAMTS13 possesses one Zn(2+) and up to three putative Ca(2+) binding sites and can be inactivated by chelating agents. Although replenishment with an appropriate metallic cation is thought to restore the enzyme's proteolytic activity fully, ADAMTS13 stabilit...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6850365/ https://ncbi.nlm.nih.gov/pubmed/31006963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14440 |
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