Mesenchymal Cell‐Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation

Human genetic evidence demonstrates that WNT1 mutations cause osteogenesis imperfecta (OI) and early‐onset osteoporosis, implicating WNT1 as a major regulator of bone metabolism. However, its main cellular source and mechanisms of action in bone remain elusive. We generated global and limb bud mesen...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Wang, Fan, Tarkkonen, Kati, Nieminen‐Pihala, Vappu, Nagano, Kenichi, Majidi, Rana Al, Puolakkainen, Tero, Rummukainen, Petri, Lehto, Jemina, Roivainen, Anne, Zhang, Fu‐Ping, Mäkitie, Outi, Baron, Roland, Kiviranta, Riku
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850336/
https://ncbi.nlm.nih.gov/pubmed/30690791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3680
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