Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide-co-glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance

Current strategies for treating autoimmunity involve the administration of broad-acting immunosuppressive agents that impair healthy immunity. Intravenous (i.v.) administration of poly(lactide-co-glycolide) nanoparticles (NPs) containing disease-relevant antigens (Ag-NPs) have demonstrated antigen (...

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Pubblicato in:Bioconjug Chem
Autori principali: Casey, Liam M., Pearson, Ryan M., Hughes, Kevin R., Liu, Jeffrey M. H., Rose, Justin A., North, Madeleine G., Wang, Leon Z., Lei, Mei, Miller, Stephen D., Shea, Lonnie D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850215/
https://ncbi.nlm.nih.gov/pubmed/29148731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00624
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