Somatic mutations precede acute myeloid leukemia years before diagnosis

The pattern of somatic mutations observed at diagnosis of acute myeloid leukemia (AML) has been well-characterized. However, the premalignant mutational landscape of AML and its impact on risk and time to diagnosis is unknown. Here we identified 212 women from the Women’s Health Initiative who were...

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Veröffentlicht in:Nat Med
Hauptverfasser: Desai, Pinkal, Mencia-Trinchant, Nuria, Savenkov, Oleksandr, Simon, Michael S., Cheang, Gloria, Lee, Sangmin, Samuel, Michael, Ritchie, Ellen K., Guzman, Monica L., Ballman, Karla V., Roboz, Gail J., Hassane, Duane C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849383/
https://ncbi.nlm.nih.gov/pubmed/29988143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0081-z
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