RDNA-06. TARGETING IDH1/2-MUTANT GLIOMAS WITH UNIQUE COMBINATIONS OF DNA REPAIR INHIBITORS

Mutations in the Isocitrate Dehydrogenase-1 and -2 (IDH1/2) genes occur in the vast majority of low-grade and secondary high-grade gliomas. These neomorphic mutations occur early on in gliomagenesis leading to the production of 2-Hydroxyglutarate (2HG). 2HG has been implicated in tumorigenesis via i...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Sule, Amrita, Bindra, Ranjit
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Radiation Biology and DNA Repair
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847809/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.866
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