SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia

Friedreich's ataxia (FRDA) is an untreatable disorder with neuro- and cardio-degenerative progression. This monogenic disease is caused by the hyper-expansion of naturally occurring GAA repeats in the first intron of the FXN gene, encoding for frataxin, a protein implicated in the biogenesis of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Bon, Carlotta, Luffarelli, Riccardo, Russo, Roberta, Fortuni, Silvia, Pierattini, Bianca, Santulli, Chiara, Fimiani, Cristina, Persichetti, Francesca, Cotella, Diego, Mallamaci, Antonello, Santoro, Claudio, Carninci, Piero, Espinoza, Stefano, Testi, Roberto, Zucchelli, Silvia, Condò, Ivano, Gustincich, Stefano
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Molecular Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847766/
https://ncbi.nlm.nih.gov/pubmed/31584077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz798
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg