PATH-54. MULTI-DIMENSIONAL MOLECULAR CHARACTERIZATION OF PATIENT-MATCHED MEDULLOBLASTOMA AT DIAGNOSIS AND RELAPSE

INTRODUCTION: Recurrent medulloblastoma (MB) confers an abysmal prognosis with ~10% 5-year overall survival. Optimal treatment paradigms for relapsed disease are largely unknown. Conservation of molecular subgroup at relapse has been described and divergent clonal evolution implicated, yet multi-dim...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Kumar, Rahul, Deng, Maximilian, Smith, Kyle, Liu, Anthony P Y, Rudneva, Vasilisa, Dhall, Girish, Kleese, Laura, Bowers, Daniel, Chintagumpala, Murali, Leary, Sarah, Nazarian, Javad, Orr, Brent, Robinson, Giles, Pfister, Stefan, Korshunov, Andrey, Gajjar, Amar, Jones, David, Northcott, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Molecular Pathology and Classification - Adult and Pediatric
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847752/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.649
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