CSIG-08. EXTRACELLULAR DOMAIN MUTATIONS IN EGFR RESULT IN A HYPERSENSITIVE RECEPTOR

INTRODUCTION: The Epidermal Growth Factor Receptor (EGFR) is a driver gene that is amplified in more than half of all glioblastomas. After the initial high copy-number amplification, secondary missense mutations in the extracellular, ligand binding domain of EGFR can evolve. We here performed analys...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: French, Pim, de Wit, Maurice, de Heer, Iris, van Royen, Martin, Vallentgoed, Wies, Hoogstrate, youri, Sillevis Smitt, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Signaling and Signaling Pathways
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847693/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.179
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