IMMU-32. RNA-NANOPARTICLE VACCINES MEDIATE T CELL TRAFFICKING NECESSARY FOR BBB PASSAGE AND ANTI-GLIOMA IMMUNE RESPONSE

BACKGROUND: The blood-brain barrier (BBB) remains a potent obstacle for development of new therapies against glioblastoma (GBM). While activated T cells can cross the BBB, immunotherapy has yet to be fully unlocked for malignant brain tumors due their heterogeneity and immunosuppressive microenviron...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Mendez-Gomez, Hector, Wummer, Brandon, Grippin, Adam, Weidert, Frances, Huang, Jianping, Deleyrolle, Loic, Mitchell, Duane, Sayour, Elias
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847633/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.524
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