IMMU-03. SUPPRESSION OF ONCOMETABOLITE 2-HYDROXYGLUTRATE PRODUCED BY MUTANT IDH1 GLIOMA WITH AGI-5198 ENHANCES THE EFFICACY OF RADIOTHERAPY AND IMMUNE CHECKPOINT BLOCKADE ELICITING IMMUNOLOGICAL MEMORY

Patients with mutant IDH1 gliomas survive ~3.8 year longer than patients harboring wildtype IDH1 glioma, irrespective of histology or genetic lesions, making mutant IDH1 an essential prognostic indicator. Mutant IDH1 gliomas are highly infiltrative with a high incidence of relapse. We are studying a...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Kadiyala, Padma, Nunez, Felipe, Garcia-Fabiani, Maria, Nunez, Fernando, Li, Dan, Schwendeman, Anna, Lowenstein, Pedro, Castro, Maria
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847445/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.497
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