ATIM-38. GLITIPNI: A PHASE 1B CLINICAL TRIAL COMBINING SURGICAL RESECTION WITH DIRECT INTRACEREBRAL INJECTION OF IMMUNE CHECKPOINT INHIBITORS IN PATIENTS WITH RECURRENT GLIOBLASTOMA

INTRODUCTION: Intravenous (iv) administration of PD-1 blocking mAb is largely ineffective for the treatment of recurrent glioblastoma (rGB). Combination of iv-ipilimumab (IPI) plus nivolumab (NIVO) is associated with a high incidence of irAE. Intracerebral (ic) administration of immune-checkpoint in...

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Vydáno v:Neuro Oncol
Hlavní autoři: Duerinck, Johnny, Awada, Gil, Katharina Schwarze, Julia, Dufait, Ines, Peeters, Stephanie, Seynave, Laura, Van Binst, Anne-marie, Everaert, Hendrik, Michotte, Alex, Rogiers, Anne, Van Velthoven, Vera, Neyns, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Adult Clinical Trials–Immunologic
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847104/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.037
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