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Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification

Identifying functional variants underlying disease risk and adoption of personalized medicine are currently limited by the challenge of interpreting the functional consequences of genetic variants. Predicting the functional effects of disease-associated protein-coding variants is increasingly routin...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hoffman, Gabriel E, Bendl, Jaroslav, Girdhar, Kiran, Schadt, Eric E, Roussos, Panos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847046/
https://ncbi.nlm.nih.gov/pubmed/31544924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz808
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