RBTT-08. A RANDOMIZED PHASE 2 OPEN LABEL STUDY OF NIVOLUMAB PLUS STANDARD DOSE BEVACIZUMAB VERSUS NIVOLUMAB PLUS LOW DOSE BEVACIZUMAB IN RECURRENT GLIOBLASTOMA (GBM)

INTRODUCTION: Initial trials with anti-PD1 in recurrent glioblastoma showed limited efficacy. Vascular endothelial growth factor (VEGF) is a highly upregulated proangiogenic growth factor in GBM that contributes to tumor-associated immunosuppression by inhibition of dendritic cell maturation and ant...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ahluwalia, Manmeet, Fallah, Jaleh, Peereboom, David, Schilero, Cathy, Ali, Assad, Forst, Deborah, Wong, Eric, Wen, Patrick, Reardon, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Randomized Brain Tumor Trials in Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846885/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.920
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