SCIDOT-06. TOWARDS EXCLUSIVELY LOCAL THERAPY OF GLIOBLASTOMA - ENGINEERING IL-12Fc WITH SUPERIOR TISSUE RETENTION AND MINIMAL SYSTEMIC EXPOSURE AFTER CNS ADMINISTRATION

Intratumoral application of IL-12 overrides the prevailing glioblastoma (GB) associated immunosuppression and can trigger efficient anti-tumor responses. With clinical studies currently testing local expression of IL-12 in brain tumors, concerns on IL-12 systemic toxicity via leakage resurface. The...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Beffinger, Michal, Schellhammer, Linda, Pantelyushin, Stanislav, Zimmermann, Iwan, Egloff, Pascal, Buch, Thorsten, Seeger, Markus, vom Berg, Johannes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Abstracts from the 3rd Sno-Scidot Joint Conference on Therapeutic Delivery to the CNS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846183/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1147
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