All-Trans Retinoic Acid Attenuates Fibrotic Processes by Downregulating TGF-β1/Smad3 in Early Diabetic Nephropathy

Diabetic nephropathy (DN) involves damage associated to hyperglycemia and oxidative stress. Renal fibrosis is a major pathologic feature of DN. The aim of this study was to evaluate anti-fibrogenic and renoprotective effects of all-trans retinoic acid (ATRA) in isolated glomeruli and proximal tubule...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Sierra-Mondragon, Edith, Rodríguez-Muñoz, Rafael, Namorado-Tonix, Carmen, Molina-Jijon, Eduardo, Romero-Trejo, Daniel, Pedraza-Chaverri, Jose, Reyes, Jose L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843855/
https://ncbi.nlm.nih.gov/pubmed/31557800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9100525
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