Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we show that tau forms complex(es) with factors involved in nuclear mRNA processing such as tumor suppressor p53 and poly(A)-specific ribonucle...

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Bibliografiska uppgifter
I publikationen:Front Mol Neurosci
Huvudupphovsmän: Baquero, Jorge, Varriano, Sophia, Ordonez, Martha, Kuczaj, Pawel, Murphy, Michael R., Aruggoda, Gamage, Lundine, Devon, Morozova, Viktoriya, Makki, Ali Elhadi, Alonso, Alejandra del C., Kleiman, Frida E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2019
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843027/
https://ncbi.nlm.nih.gov/pubmed/31749682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00242
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