Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation

BACKGROUND: 15-lipoxygenase 1 (15LO1) is expressed in airway epithelial cells in Type-2-High asthma, in association with eosinophilia. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also associated with Type-2 inflammation and eosinophilia. CCL26/Eotaxin3 has been reported to be regulated by 1...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Li, Zhipeng, Zeng, Ming, Deng, Yanhan, Zhao, Jinming, Zhou, Xiuxia, Trudeau, John B., Goldschmidt, Ezequiel, Moore, John A., Chu, Hongwei, Zhang, Weitian, Yin, Shankai, Liu, Zheng, Di, Y. Peter, Lee, Stella E., Wenzel, Sally E.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842430/
https://ncbi.nlm.nih.gov/pubmed/31301373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.06.037
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