CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis

Dysregulated immune responses are essential underlying causes of a plethora of pathologies including cancer, autoimmunity, and immunodeficiency. We here investigated 4 patients from unrelated families presenting with immunodeficiency, autoimmunity, and malignancy. We identified 4 distinct homozygous...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Somekh, Ido, Thian, Marini, Medgyesi, David, Gülez, Nesrin, Magg, Thomas, Gallón Duque, Alejandro, Stauber, Tali, Lev, Atar, Genel, Ferah, Unal, Ekrem, Simon, Amos J., Lee, Yu Nee, Kalinichenko, Artem, Dmytrus, Jasmin, Kraakman, Michael J., Schiby, Ginette, Rohlfs, Meino, Jacobson, Jeffrey M., Özer, Erdener, Akcal, Ömer, Conca, Raffaele, Patiroglu, Türkan, Karakukcu, Musa, Ozcan, Alper, Shahin, Tala, Appella, Eliana, Tatematsu, Megumi, Martinez-Jaramillo, Catalina, Chinn, Ivan K., Orange, Jordan S., Trujillo-Vargas, Claudia Milena, Franco, José Luis, Hauck, Fabian, Somech, Raz, Klein, Christoph, Boztug, Kaan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839947/
https://ncbi.nlm.nih.gov/pubmed/31501153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000644
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