DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited. DESIGN: We performed genome-wide DNA methyla...

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Bibliographic Details
Published in:Gut
Main Authors: Kraiczy, Judith, Nayak, Komal M, Howell, Kate J, Ross, Alexander, Forbester, Jessica, Salvestrini, Camilla, Mustata, Roxana, Perkins, Sally, Andersson-Rolf, Amanda, Leenen, Esther, Liebert, Anke, Vallier, Ludovic, Rosenstiel, Philip C, Stegle, Oliver, Dougan, Gordon, Heuschkel, Robert, Koo, Bon-Kyoung, Zilbauer, Matthias
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2019
Subjects:
Intestinal Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839835/
https://ncbi.nlm.nih.gov/pubmed/29141958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-314817
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